Immunosuppression and Transfusion

Inflammatory response, immunosuppression, and cancer recurrence after perioperative blood transfusion.

Association between gene expression biomarkers of immunosuppression and blood transfusion in severely injured polytrauma patients

OBJECTIVE To explore the hypothesis that blood transfusion contributes to an immunosuppressed phenotype in severely injured patients. BACKGROUND Despite trauma patients using disproportionately large quantities of blood and blood products, the immunomodulatory effects of blood transfusion in this group are inadequately described. METHODS A total of 112 ventilated polytrauma patients were re...

Use of an inbred mouse model system for studies of allogeneic transfusion-induced immunosuppression.

Two studies published recently in Blood' and Transfiision2 describe application of an inbred mouse model of allogeneic transfusion to investigate the role ofdonor leukocytesin inducingimmunosuppressive consequences of transfusion. Blajchman et al' showed a median fivefold increase in the frequency of pulmonary metastases at 21 days in C57/BI/J6 (H-2b) mice that were transfused with allogeneic (...

Immunosuppression minimization: current and future trends in transplant immunosuppression.

The past decade has witnessed unprecedented advances in renal transplantation propelled by novel and effective immunosuppression drugs. The introduction of mycophenolate mofetil (MMF), tacrolimus, cyclosporine microemulsion, sirolimus, a new generation of monoclonal antibodies (the anti–interleukin-2 receptor blockers, daclizumab and basiliximab), and the depleting polyclonal biologic Thymoglob...

Sunscreen and immunosuppression.

Recently, Walker and Young (1997) reported that ultraviolet (UV) B sunscreens offer the same UVB protection factors against inflammation and immunosuppression in the mouse . The authors studied the relationship between photoprotection of inflammation and immunosuppression with monochromatic (Phi lips TL-01 tubes, A..,. _,= 311mll) UVB radiation. T he UVB dose-response curve for murine edema was...